Department of Bioorganic chemistry

Academic Staff

Associate professor Stela Dimitrova, PhD – Head of Department

Professor Rumen Mladenov, PhD

Associate professor Yordanka Uzunova, PhD – Educational Activities

Professor Plamen Stoyanov, PhD – International Cooperation and Project Activity

Chief assistant professor Mariana Katsarova, PhD – Chief Assistant Professor for Administrative Activities and scientific measurement and observation tool

Chief assistant professor Tsvetelina Mladenova, PhD

Chief assistant professor Krasimir Todorov, PhD

Assistant professor Mariya Vlasheva, PhD – Science and research activities, Update of the web page of the department

Assistant professor Miglena Milusheva, PhD – Quality and accreditation

Assistant professor Nikolay Toshev, PhD – E-learning

Ekaterina Georgieva – chemist, Fire safety

Yordanka Alexieva – laboratory assistant

Svetla Kostadinova – laboratory assistant

Research

The current research topics in the Department of Bioordanic Chemistry are related to:

– Chemical composition and biological activity of medicinal plants
– Biopolymers in medicine
– Analysis of metabolites in biological samples

Textbooks

1. Labbook for practical classes in Bioorganic chemistry, M. Argirova, Y. Uzunova, ISBN 978-954-9549-28-7, First edition, Plovdiv 2015.

Publications

• Todorov, K., Stoyanov, P., Mladenov, R., Gyuzeleva, D., Radoukova, Tz., Selyami, Dzh., Zhelyazkova, S., Mladenova, Ts. (2025). Analysis of medicinal plants from the regions of the Strandzha mountain and southern Black Sea Coast, Bulgaria. Ecologia Balkanica, 17(1): 066-078.
• Milusheva, M., Todorova, M., Gledacheva, V., Stefanova, I., Feizi-Dehnayebi, M., Pencheva, M., … & Nikolova, S. (2023). Novel anthranilic acid hybrids—An alternative weapon against inflammatory diseases. Pharmaceuticals, 16(12), 1660.
• Milusheva, M., Gledacheva, V., Stefanova, I., Feizi-Dehnayebi, M., Mihaylova, R., Nedialkov, P., … & Nikolova, S. (2023). Synthesis, molecular docking, and biological evaluation of novel anthranilic acid hybrid and its diamides as antispasmodics. International Journal of Molecular Sciences, 24(18), 13855.
• Kandilarov, I., Gardjeva, P., Georgieva-Kotetarova, M., Zlatanova, H., Vilmosh, N., Kostadinova, I., … & Dimitrova, S. (2023). Effect of plant extracts combinations on TNF-α, IL-6, and IL-10 levels in rats exposed to acute and chronic stress serum. Plants, 12(17), 3049.
• Tomov, D. G., Levterova, B. A., Troev, D. M., Miteva, M. Z., Mihaylova, V. N., Uzunova, Y. I., … & Orbetzova, M. M. (2023). Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto’s thyroiditis. Folia Medica, 65(2), 199-206.
• Vlasheva, M., Katsarova, M., Dobreva, A., Dzhurmanski, A., Denev, P., & Dimitrova, S. (2024). Echinacea Species Cultivated in Bulgaria as a Source of Chicoric and Caftaric Acids. Agronomy, 14(9), 2081.
• Vlasheva, M., Katsarova, M., Kandilarov, I., Zlatanova-Tenisheva, H., Gardjeva, P., Denev, P., … & Dimitrova, S. (2024). Echinacea purpurea and Onopordum acanthium Combined Extracts Cause Immunomodulatory Effects in Lipopolysaccharide-Challenged Rats. Plants, 13(23), 3397.
• Budak, A., Mihaylova, A., Doncheva, N., Katsarova, M., Vlasheva, M., Dimitrova, S., … & Kostadinov, I. (2024). NIGELLA SATIVA OIL ALLEVIATES PAIN IN PACLITAXEL-INDUCED NEUROPATHY IN RATS. „VIII Национален конгрес по фармакология, клинична фармакология и терапия “„Фармакологията–от експеримента към клиниката”, 15-17 ноември 2024 г., 5.
• Mihaylova, A., Doncheva, N., Vlasheva, M., Katsarova, M., Gardjeva, P., Dimitrova, S., & Kostadinov, I. (2025). Investigation of the Immunomodulatory and Neuroprotective Properties of Nigella sativa Oil in Experimental Systemic and Neuroinflammation. International Journal of Molecular Sciences, 26(5), 2235.
• Tomov, D. G., Levterova, B. A., Mihailova, V. N., Troev, D. M., Miteva, M. Z., Uzunova, Y. I., & Orbetzova, M. M. (2024). Influence of the increase in intestinal permeability and microbiota change in the development of Hashimoto’s thyroiditis-Systematic review. Endocrine and Metabolic Science, 100195
• Tomova, Z., Tomov, D., Davcheva, D., & Uzunova, Y. (2024). Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations—A Pilot Study. Dentistry Journal, 12(11), 362.
• Milusheva, M., Stoyanova, M., Gledacheva, V., Stefanova, I., Todorova, M., Pencheva, M., … & Nikolova, S. (2024). 2-Amino-N-Phenethylbenzamides for Irritable Bowel Syndrome Treatment. Molecules, 29(14), 3375.
• Teneva, O., Petkova, Z., Toshev, N., Solakov, N., Loginovska, K., & Platov, Y. (2024). Effect of roasting on the chemical and lipid composition of pine nuts in two regions in Russia. Heliyon, 10(14).
• Stoyanova, M., Milusheva, M., Georgieva, M., Ivanov, P., Miloshev, G., Krasteva, N., … & Nikolova, S. (2025). Synthesis, Cytotoxic and Genotoxic Evaluation of Drug-Loaded Silver Nanoparticles with Mebeverine and Its Analog. Pharmaceuticals, 18(3), 397.
• Stoyanova, M., Milusheva, M., Gledacheva, V., Todorova, M., Kircheva, N., Angelova, S., … & Nikolova, S. (2025). Silver Nanoparticles with Mebeverine in IBS Treatment: DFT Analysis, Spasmolytic, and Anti-Inflammatory Effects. Pharmaceutics, 17(5), 561.
• Petkov, V., Slavova, I., Teneva, D., Mladenova, T., Stoyanov, P., & Argirova, M. (2022). Phytochemical study and biological activity of three fern species of the Asplenium genus growing in Bulgaria. The Natural Products Journal, 12(6), 82-90.
• Andonova, T., Muhovski, Y., Slavov, I., Vrancheva R., Georgiev, V., Apostolova, E., Naimov, S., Mladenov, R., Pavlov, A., Dimitrova-Dyulgerova, I. (2023). Phenolic profile, antioxidant and DNA-protective capacity, and microscopic characters of Ailanthus altissima aerial substances. Plants, 12, 920. Online ISSN: 2223-7747. Q1 IF 4.5 Q1 SJR 0.79
• Teneva, I., Belkinova, D., Paunova-Krasteva, T., Bardarov, K., Moten, D., Mladenov, R., Dzhambazov, B. (2023). Polyphasic characterisation of Microcoleus autumnalis (Gomont, 1892) Strunecky, Komárek & JR Johansen, 2013 (Oscillatoriales, Cyanobacteria) using a metabolomic approach as a complementary tool. Biodiversity Data Journal, 11, e100525. Online ISSN 1314-2828, Q3 IF 1.3 Q2 SJR 0.46
• Rusinova-Videva, S., Petkova, Zh., Antova, G., Stoyanov, P., Mladenova, Ts., Radoukova, Tz. (2023). Effect of polyoxyethylene sorbitan monooleate (Tween 80) on exopolysaccharide and biomass composition of psychrophilic yeast. Polish Polar Research, 44(4): 385-399 Q4 IF 1.3 Q3 SJR 0.288
• Stavrakeva, K., Metodieva, K., Benina, M., Bivolarska, A., Dimov, I., Choneva, M., … & Apostolova, E. (2024). Metabolic composition of methanolic extract of the Balkan endemic species Micromeria frivaldszkyana (Degen) Velen and its anti-inflammatory effect on male Wistar rats. International Journal of Molecular Sciences, 25(10), 5396.
• Belkinova, D., Stoianova, D., Beshkova, M., Kazakov, S., Stoyanov, P., & Mladenov, R. (2024). Current status and prognosis of Raphidiopsis raciborskii distribution in Bulgaria as part of the southeastern region of Europe. Harmful Algae, 132, 102578.
• Teneva, O., Petkova, Z., Antova, G., Angelova-Romova, M., Stoyanov, P., Todorov, K., … & Gyuzeleva, D. (2024). Chemical Composition and Lipid Bioactive Components of Centaurea thracica Dwelling in Bulgaria. Molecules, 29(14), 3282.

Monographs

1.Stoyanov, P. (2019). Algae and higher spore plants of the “Bulgarka” Nature Park. “Lax Book” Publishing House, ISBN 978-619-189-120-7, Plovdiv, 119 pp.

Dissertations

PhD-Dissertations:

Chemistry:

1. Assoc. Prof. Yordanka Uzunova, PhD – 2013, Determination of residual monomers after polymerization of dental composites.
2. Assoc. Prof. Stela Dimitrova, PhD – 2014, Identification and antioxidant activity of isoprenoids from psychrophilic yeast biomass
3. Chief Asst. Prof. Mariana Katsarova, PhD – 2017, Chemical composition, antioxidant potential, and biological activity of plants with anxiolytic action
4. Asst. Prof. Nikolay Toshev, PhD – 2021, Theoretical study of the factors governing the binding processes and selectivity of histone deacetylase inhibitors
5. Asst. Prof. Mariya Vlasheva, PhD – 2025, Chemical and pharmacological study of individual and combined extracts from Echinacea purpurea and Onopordum acanthium
6. Asst. Prof. Miglena Milusheva, PhD – 2025, Synthesis of novel antispasmodics affecting memory functions in experimental animals

Botany:

1. Prof. Rumen Mladenov, PhD – 1997, Variability and taxonomy of species from the subgenus Obliquodesmus Mlad. of the genus Scenedesmus Meyen (Chlorophyta)
2. Prof. Plamen Stoyanov, PhD – 2014, Variability, taxonomy and ecology of some filamentous blue-green algae (Cyanoprokaryota)
3. Chief Asst. Prof. Krasimir Todorov, PhD – 2018, Biosystematic study of the genus Carduus L. (Asteraceae) in Bulgaria
4. Chief Asst. Prof. Tsvetelina Mladenova, PhD – 2021, Phytochemical and biological study of rare essential oil and medicinal plants from the Bulgarka Nature Park