Department of Clinical Laboratory

Academic Staff

Prof. Tanya Deneva, MD, PhD – Head of Department

Chief Administrative Assistant Professor Delyana Davcheva, MD, PhD

Chief Assistant Professor Snezhana Stoencheva, MD, PhD

Lecturer Desislava Arabadzhiyska, MD

Lecturer Boyan Delev, MD

Lecturer Vanya Peneva, MD

Assist. Prof. Raya Delipavlova, MD

Assist. Prof. Eleonora Chakarska, MD

V. Markova, MD, Assist. Prof.

Technical staff:

Diana Mareva, chemist

Ralitsa Maksimova, chemist

Mariya Kacharova – chemist

Rumyana Ivanova, biologist

Veska Shtarbeva, technical secretary

Kadrieh Rasim, hygienist

Research

The research activity of the Department is diverse.

One of the main directions in scientific research is the assessment of the analytical characteristics of modern analytical techniques and their application in clinical laboratory practice.

Another area of activity of the Department is related to the study of the involvement of oxidative stress in the pathogenesis of socially significant endocrine and liver diseases.

А scientific interest is clarifying the involvement of melatonin in the pathogenesis of neurological and endocrine diseases. An important role in the scientific activity of the Department is the clinical and laboratory evaluation of some hemostatic parameters in patients with malignant diseases.

Studies have been performed on thyroid function and the effect of thyroid dysfunction on some markers of bone metabolism.

Over the past 5 years, more than 50 scientific articles have been published by the members of the Department, 17 of which are in IF journals. During this period, the academic staff of the Department has participated with over 70 scientific reports in national and international forums.

Textbooks

1. T. Deneva, V. Markova, D. Davcheva, V. Peneva, B. Delev, D. Arabadzhiyska, S. Stoencheva.Clinical laboratory interpretation of results.Lax Book Plovdiv. 2021
2. Bishop M., E. Fody, L. Schoeff. Clinical chemistry: principles, techniques, and correlations. 7th ed. Edited by Lippincott Williams&Wilkins. 2013
3. Theml Н., Н. Diem, Т. Haferlach. Color Atlas of Hematology. Practical Microscopic and Clinical Diagnosis. 2th revised ed. Thieme, Stuttgart, 2004
4. Henry’s Clinical Diagnosis and Management by laboratory methods, 21st ed., edited by Richard Mcpherson and Matthew Pincus
5. Kaplan LA, Pesce AJ (ed). Clinical Chemistry. Theory, analysis, and correlation. 3th edition. St. Louis, Missouri, Mosby-Year Inc., 1996
6. Burtis CA, Ashwood ER&DEBruns (ed). Tietz Textbook of Clinical Chemistry and molecular diagnostics. 4th ed. Elsevier Sounders, 2006
7. Mcpherson R. and M. Pincus. Henry’s Clinical diagnosis and Management by laboratory methods, 21st ed.
8. S. K. Strasinger, M. Sch. Di Lorenzo. Urinalysis and Body Fluids. 5th ed. E. A. Davis Company-Philadelphia, 2008
9. Atanasova B. D., Nikolina Iv. Denikova, Blagovesta S. Dishlianova, Svetlana D. Hadjieva, Mariana P. Genova et al. Guide to practical trainings in clinical chemistry for pharmacy students, Lax book, 2014.
10. Marshall William J., Andrew Day, Marta Lapsley. Clinical chemistry / – 8th ed.- Edinburgh: Elsevier, 2017.
11. McClatchey Kenneth. Clinical laboratory medicine /. – 2nd ed. Lippincott Williams & Wilkins, 2002.

Publications

Terzieva D. D., N. G. Mateva, L. G. Vladimirova-Kitova. Melatonin reference limits at 3:00 AM AND 8:00 AM in healthy adults. Clin. Lab. 2009, 55 (9+10): 359-361; IF2009 = 1.010
Atanassova P. A., D. D. Terzieva and B. D. Dimitrov. Impaired nocturnal melatonin in acute phase of ischaemic stroke: cross-sectional matched case-control analysis. J. Neuroendocrinol 2009, 21 (7): 657-663; IF2009 = 3.700

Terzieva D.D., M.M. Orbetzova, M. D. Mitkov, N. G. Mateva. Serum melatonin in women with polycystic ovary syndrome. Folia medica 2013, 55 (2): 10-15
Vladimirova-Kitova L., D. Terzieva, B. Marinov. Intima-media thickness and flow-mediated vasodilation in asymptomatic subjects with newly detected severe hypercholesterolemia Echocardiography 2009; 26 (9): 1060-68; IF2009 = 1.444

Grudeva – Popova J. G., D. D. Terzieva, I. S. Nenova. Changes of serum prohepcidin, iron status and zinc-protoporphyrin in a random group of patients with malignant diseases. Journal of BUON 2011; 16: 361-365; IF2011 = 0.607

K. N. Georgieva, P. A. Angelova, F. D. Gerginska, D. D. Terzieva, M. S. Shishmanova-Doseva, S. D. Delchev, V. V. Vasilev. The effect of flutamide on the physical working capacity and activity of some of the key enzymes for the energy supplay in adult rats. Asian J Androl 2016; 18: 1-5; IF2016 = 2,996

D. M. Davcheva, G. K. Kirova, T. Z. Tsvetkova, D. D. Terzieva, M. T. Kiryakova, V. J. Kmetov. Sample preparation and calibration optimization for ICP-MS analysis of copper, zinc, selenium, rubidium, strontium, magnesium, iron, molybdenum and barium in human serum. Bulgarian Chemical Communications 2019, v.5. Special issue D, pp 52-57; IF2017/2018 = 0.242

Shishmanova-Doseva, M., Peychev, L., Koeva, Y., Terzieva, D., Georgieva, K., Peychev, Z. Chronic treatment with the new anticonvulsant drug lacosamide impairs learning and memory processes in rats: A possible role of BDNF/TrkB ligand receptor system (2018) Pharmacology Biochemistry and Behavior, 169, pp. 1-9. DOI: 10.1016/j.pbb.2018.03.009; IF2018/2019 = 2.773

Michaela Shishmanova-Doseva, Katerina Georgieva, Yveta Koeva, Dora Terzieva, Lyudmil Peychev. Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway. Behavioural Brain Research v. 370 (16 September 2019) 111963; IF2018 = 2.770

Koleva D.I., Orbetzova M.M., Nikolova J.G., Deneva T.I. Pathophysiological Role of Adiponectin, Leptin and Asymmetric Dimethylarginine in the Process of Atherosclerosis. Folia medica, 2016; (4): 234-240

Deneva T, Ianakiev Y, Keskinova D. Burnout Syndrome in Physicians —Psychological Assessment and Biomarker Research. Medicina 2019, 55, 209; doi:10.3390/medicina55050209; IF = 1.429

Stoencheva S, Deneva T, Beleva E, Grudeva Popova Zh, Popov V. Determination of Plasma Tissue Factor Antigen and Tissue Factor-Bearing Microparticles Activity in Healthy Subjects. Biomed J Sci & Tech Res 2019:19(3) ISSN: 2574 -1241 DOI: 10.26717/BJSTR 2019.19.003292; IF = 0.548

Zlatanova H, Vladimirova S, Kostadinov I, Delev D, Deneva T, Kostadinova I. Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent. Medicina 2019, 55, 93; doi:10.3390/medicina 55040093; IF = 1.429

Peycheva M, Deneva T, Zahariev Z. High-sensitive CRP in ischaemic stroke patients – from risk factors to evolution. Cesk Slov Neurol N 2019; 82/ 115(5):549– 555; IF = 0.508

Monographs

Dissertations

DMedSc theses:
Model study of optimizing the place of clinical laboratory investigations and the programs for mass dispanserisation, N. Atanasov (1989)
Aspects of granulocyte function in norm and pathology, T. Tsvetkova (1991)

PhD theses:
Cytochemical characteristics of blood cells in acute leukemia and chronic myelosis, T. Tsvetkova (1981)
Porphyrins in renal diseases, M. Pisanets (1981)
Gas chromatographic methods for drug monitoring of anticonvulsants, G. Minkova (2001)

Homocysteine – methodical and clinical diagnostic aspects, E. Angelova (2007)

Towards a clinical and laboratory evaluation of endothelial dysfunction, T. Deneva (2009)
Study on serum melatonin concentration in norm and pathology, D. Terzieva (2014)